Rheumatoid Arthritis | Human Biospecimens | Order Online
autoimmune diseases rheumatoid arthritis

Rheumatoid Arthritis

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Rheumatoid arthritis is a chronic, progressive, inflammatory disease affecting the adult population worldwide. It is an inflammatory arthritis characterized by polyarticular systemic joint involvement and systemic manifestation, but the causes remain unknown.

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Research shows rheumatoid arthritis is an autoimmune disease in which the dysregulation of humoral and cell-mediated immunity results in the production of rheumatoid factor antibodies, which in return trigger the immune system to attack its healthy tissues. The growing prevalence has led to a hike in research opportunities in the rheumatoid diagnostic test market and therapeutic research.

Rheumatoid arthritis affecting human life:

  • Rheumatoid arthritis joints: RA primarily affects the joints' lining, causes painful swelling or inflammation resulting in bone erosion, destruction of synovial joints, and joint deformities. Severe acute rheumatoid arthritis progresses to chronic rheumatoid arthritis leading to severe disability, aging, and premature mortality.

  • Rheumatoid arthritis patients exhibit difficulty in performing their everyday activities like walking, sitting, standing, running, etc., which in turn decreases their health-related quality of life.  

  • It affects everyone regardless of age. However, people more than 40 years old face severe rheumatoid arthritis implications. Women and people having a family history of arthritis are more likely to develop the disease.

  • In general, rheumatoid arthritis can cause a detrimental impact on one's physical, social, and mental well-being.

Signs and Symptoms of Rheumatoid arthritis:

Most individuals experience an insidious onset of disease with general malaise, fatigue, low-grade fever, anorexia, and non-specific musculoskeletal pain. Articular manifestations of rheumatoid arthritis characterize pain, swelling, warmth, and tenderness of joints with joint stiffness that worsens in the morning. In chronic arthritis, the inflammation of synovial tissues tends to be symmetrical and affects the human body's peripheral joints such as hands, elbows, feet, legs, knees, etc.  Rheumatoid arthritis hands gradually develop deformity. 

Being a systemic disease, rheumatoid arthritis can affect other organs of the body. The extra-articular manifestations of the disease are rheumatoid nodule, vasculitis, pleural effusion, pulmonary fibrosis, cardiac problems, and ocular manifestations.


Rheumatoid arthritis Treatment:

There is no permanent cure for Rheumatoid arthritis. However, the disease progression can be effectively managed by anti-rheumatoid therapy coupled with lifestyle modifications aiming at improving the quality of life of rheumatoid arthritis patients. Pharmacotherapies with disease-modifying antirheumatic drugs (DMARDs), biological agents, nonsteroidal anti-inflammatory agents (NSAIDs) are the mainstay for effective management of chronic rheumatoid arthritis and its flare-ups.


An insight into Rheumatoid Arthritis Biospecimens we offer:

Central BioHub offers a meticulous collection of seropositive and seronegative biological samples from people of different ages and genders. Our invaluable access to biospecimens makes life science researchers procure the intended biological samples without difficulty. Central BioHub endeavors to offer hyper-annotated human biospecimen that are explicitly measured for rheumatoid arthritis diagnosis routine that includes Rheumatoid factor antibody (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and anti-citrullinated protein/peptide antibodies (ACPA/anti-CCP).

Rheumatoid arthritis samples such as serum and plasma samples of arthritic patients are ideal for performing in-vitro drug discovery studies. Biological samples containing plasma concentrations of disease-modifying antirheumatic drugs (DMARDs) and biological agents such as Methotrexate, Adalimumab, Infliximab, Golimumab, etc., are available. We also provide quantitative clinical assessment data such as Disease Activity Score-28 (DAS28) of rheumatoid arthritis patients to understand the extent of joint involvement and disease progression.

Introducing you to the most straightforward virtual interface, Central BioHub eases the access of global researchers and scientists to human biological samples. We bridge between various renowned biospecimen suppliers and global researchers to purchase safe, reliable, high-quality, and cost-effective Rheumatoid arthritis Blood test samples for research.

Explore advanced search options to order biospecimens from rheumatoid arthritis by clicking clinical diagnosis, ICD-10-CM codes, and laboratory parameters.

 

Rheumatoid arthritis is a chronic, inflammatory, autoimmune disease causing pain and swelling at the joints. It affects anyone of any age, affecting patients quality of life. The disease mainly affects joints of hands, knees, or ankles symmetrically (on both sides of the body at the same time equally).
Hand rheumatoid arthritis is manifested by symmetrical painful swelling at the joints of wrists, large knuckles (metacarpophalangeal joints), and middle knuckles (proximal interphalangeal joints) accompanied by morning stiffness. The patient experiences difficulty in making a fist and performing small activities like using a smartphone, writing, typing, or preparing meals. If not treated, it can develop into rigid, rounded painful rheumatoid nodules at the affected areas, including fingers, wrists, forearms, and elbows, followed by joint deformities.
Multiple diagnostic tests such as blood tests, physical examination of affected joints, and radiological examinations are involved in diagnosing rheumatoid arthritis. In rheumatoid patients, the blood test is used to check the presence of nuclear antibodies, level inflammatory mediators, and rheumatoid factors. Radiological diagnoses such as X-rays and MRI scans help in tracking the extent of disease progression on the joints.
Rheumatoid arthritis biospecimens are human serum and plasma samples isolated from the consented donors, ideal for in-vitro biomedical research. The biosamples are critically measured for arthritic laboratory investigations like rheumatoid factor antibody (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and anti-citrullinated protein/peptide antibodies (ACPA/anti-CCP) and stored at <-180C at our partners biobank.
There is no complete cure for rheumatoid arthritis. However, early diagnosis and initiation of rheumatoid arthritis treatment can prevent your joint from permanent damage. Anti-rheumatoid drugs like disease-modifying anti-rheumatic drugs (DMARDS), biological agents, nonsteroidal anti-inflammatory drugs (NSAIDs), and low dose corticosteroids can slow down disease progression and lower the intensity of arthritic pain. Common DMARDs include methotrexate, leflunomide, hydroxychloroquine, and sulfasalazine.