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metabolic disorders diabetes i

Diabetes I

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Type 1 diabetes mellitus is also known as insulin dependent diabetes mellitus (IDDM), affects sugar metabolism. It mainly develops due to autoimmune-mediated destruction of pancreatic beta cells with the production of autoantibodies like islet cell antibodies and insulin antibodies against beta-cell antigens by macrophages and T-lymphocytes.

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Although illness onset can be at any age, Type 1 diabetes mellitus strikes children and young adults the most. Therefore, it is also known as juvenile diabetes. Moreover, the present decade is witnessing a hike in the incidence of type 1 diabetes, influencing the health-related quality of life of the young generation. 

Signs and Symptoms of Type 1 Diabetes Mellitus:

Juvenile diabetes symptoms often shows a sudden  and is similar as type 2 diabetes symptoms that includes:

  • Polyphagia (extreme hunger)

  • Polydipsia (increased thirst)

  • Polyuria (frequent urination, sometimes unusual bedwetting in children)

  • Sudden unintended weight loss

  • Lethargy and weakness

  • Hyperglycemia-increase in blood sugar level

  • Irritability and mood swings

  • Blurred vision

Type 1 diabetes treatment modalities:

A permanent cure for type 1 diabetes mellitus is not possible. However, type 1 diabetes treatment options mainly focus on controlling blood sugar levels, preventing complications, reducing mortality, and improving the patient's quality of life. Therefore, lifelong therapy with insulin analogues is required for treating illness. Depending upon the blood sugar level, dosage fixation, and choice of insulin such as short-acting (regular), rapid-acting, intermediate-acting, and long-acting insulin are decided. Often insulin is administered subcutaneously and, if necessary, intravenously to maintain normal blood glucose levels. Besides, strict adherence to the diet plan and regular exercise is crucial for achieving antidiabetic treatment’s goal.


An insight into Type 1 Diabetes Biospecimens we offer:

Helping diabetic researchers across the globe, Central BioHub provides trustworthy premium quality, clinically graded type 1 diabetes patient samples for research. The clinical research samples include human serum and plasma (K3 EDTA, K2 EDTA, EDTA, Li-heparin plasma samples obtained from various consented donors, clinically suspected or confirmed with type 1 diabetes mellitus. Moreover, the diabetes samples we provide are hyper-annotated with patients' medical information, including medication history and demographic data such as age, gender, ethnicity, and country of sample origin.

Adhering to the customized standard procedures for sample collection and processing, the serum and plasma samples are tested for routine laboratory investigation parameters for diagnosing type 1 diabetes. The type 1 diabetes specimens we offer are critically screened for diabetic biomarkers, like islet cell cytoplasmic autoantibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase autoantibodies (GADA) at certified, world-class laboratories, and well maintained at <-18 °C at our biorepository. Procure your clinical research sample today from Central BioHub, the largest online biospecimens marketplace. Reach out to us for finding type 1 diabetes research samples  and other  human biospecimens  for clinical research.

Explore advanced search options to order type 1 diabetes samples by clicking Clinical Diagnosis, ICD-10-CM Codes, and Laboratory Parameters.

Type 1 diabetes mellitus, or insulin-dependent diabetes mellitus (IDDM), is a metabolic disorder characterized by an increase in blood glucose levels. Autoimmune destruction of pancreatic beta cells by the immune system causes it. Pancreatic beta cells are responsible for producing insulin to regulate blood glucose. Therefore, its destruction results in an imbalance between insulin demand and production, eventually causing hyperglycemia. Although illness onset can be at any age, children and young adults are disproportionately affected by type 1 diabetes mellitus. This is why it is called juvenile diabetes.
The incidence of type 1 diabetes mellitus is higher in children and young adults who have a family history of the disease.
Type 1 Diabetes mellitus is an autoimmune disorder resulting from immune-mediated destruction of pancreatic beta cells. In comparison, insulin resistance or inadequate insulin production causes type 2 diabetes mellitus. The onset of type 1 diabetes mellitus occurs most often in children and young adults; the onset of type 2 diabetes mellitus occurs most often in adults.
Type 1 diabetes mellitus samples are serum and plasma samples collected from clinically confirmed patients and suspected individuals indented for research use. All the samples are subjected to diabetic biomarker testing, such as autoantibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase autoantibodies (GADA), and are stored at <-180 C.
Blood sugar testing is the mainstay for the disgnosis of type 1 diabetes mellitus. It includes fasting blood sugar (FBS), random blood sugar (RBS), and postprandial blood sugar (PPBS). Additionally, diabetic biomarker tests like autoantibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase autoantibodies (GADA) yield specific confirmation of the disease.