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Lyme Disease

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Lyme disease (ICD Code - A69.2), also known as Lyme borreliosis, is the most common vector-borne bacterial infection commonly caused by a spirochete Borrelia burgdorferi and rarely, Borrelia mayonii, Borrelia afzelii, Borrelia garinii.

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It is a multisystem infection transmitted to humans through the bite of the infected black legged ticks (Ixodes scapularis) or deer ticks. Lyme disease is prevalent in southern parts of the United States and Europe, with a higher incidence in children aged 5-10 years than adults. The growing prevalence of the disease has resulted in raising public health concerns to prevent infection sequelae. 

Clinical Diagnosis of Lyme Disease:
Timely accurate diagnosis and appropriate management of infection are the critical factors to minimize any disease progression. Apart from physical examination and history of tick bite exposure in current clinical practice, dual step serological testing is widely employed to optimize the specificity and sensitivity of laboratory testing. The two-step approach incorporates screening by enzymatic immunoassay (EIA), followed by a confirmatory western blot test to detect serum antibodies such as anti-borrelia IgG/ IgM, anti-borrelia burgdorferi sensu lato IgG/ IgM produced in response to borrelia infection. The accuracy of diagnostic tests depends upon the extent of illness progression and the production of antibodies in the blood.
However, Lyme disease diagnosis always remains challenging, and the quest for more reliable, fast, and accurate diagnostic tests widens up enormous scope for diagnostic scientists worldwide.

Lyme disease symptoms in humans:
Illness onset is with tick exposure and with the appearance of cutaneous manifestations like red macular or papular skin lesion on the site of tick bite and advances to large erythematous annular lesions in later stages. Lyme disease symptoms can be early localized disease, early disseminated disease, and late disease, depending upon the phases of infection.
The early localized disease manifested as erythema migrans appearing at the tick bite site in three to thirty days post tick exposure and is associated with flu-like symptoms like fever, fatigue, headache, myalgia, or arthralgia. In the early disseminated stage, infected patients exhibit multiple erythema migrans, meningitis, cranial nerve palsies,  carditis, and meningitis requiring ambulatory or hospitalized care. The late disease is primary monoarticular or sometimes oligoarticular arthritis affecting larger joints like knee joints. In most patients, the infections resolve after initiating appropriate antimicrobial therapy  2-4 weeks or based on the clinical response of the patients.

Insight to the Lyme disease Biospecimens We Offer:
Defining new spheres for life science discovery, Central BioHub introduces you to the most reliable virtual interface for speedy procurement of Lyme disease research samples online. Focusing on maximizing the potential for diagnostic and pharmaceutical research on Lymes infection, Central BioHub brings you human serum and plasma biosamples of suspected and confirmed patients of variable ethnicity, gender, BMI, and age groups.
We offer human biospecimens of Lyme disease obtained ethically from consented donors complying with the Center for Disease Control and Prevention (CDC) standards. We are dedicated to providing human serological samples and human plasma-EDTA biospecimens assiduously screened for anti-Borrelia IgG/ IgM, anti-Borrelia burgdorferi sensu lato IgG/ IgM with ultimate precision. The biospecimens we offer are available in small volume samples stored in perfect condition at <-18°C at Lyme disease biobank. Benefiting scientists in indigenous research on Lyme disease, Central BioHub provides details about the country or region of biosamples origin.Assimilating real-world data on Lyme disease biospecimens, our scientific experts at Central BioHub assist you in every step of your sample procurement. We commit to the worldwide supply of safe, reliable, cost-effective lyme disease samples. Moreover, all human biospecimen inventory is processed at Central BioHub in strict adherence to Helsinki's declaration and the Declaration of Taipei.

Also, explore advanced search options to order Lyme disease tests samples by clicking clinical diagnosis, ICD-10-CM codes, and laboratory parameters.

It is a tick-borne bacterial infection prevalent in the United States and Europe caused by the bacterium spirochete Borrelia burgdorferi and rarely, Borrelia mayonii, Borrelia afzelii, Borrelia garinii. It is transmitted to humans by the bite of infected black-legged ticks, commonly known as deer ticks.
The best way to prevent Lyme diseases is to avoid ticks biting. • Avoid long walks through the woods. • Apply tick repellents on the skin and clothing. • Use permethrin spray on clothing or camping gear. • Wear long pants and full sleeves while walking through woods or bushy forest areas.
Symptoms of Lyme disease usually appear 3-30 days after the infected tick bite. If not treated, it can cause late Lyme disease symptoms for weeks and last for many years after initial infection.
Lyme disease samples are the human biospecimens for research obtained through customised sampling from Lyme disease patients of every gender, sex, and ethnicity. The human and serum samples assiduously screened for anti-Borrelia IgG/ IgM, anti-Borrelia burgdorferi sensu lato IgG/ IgM with ultimate precision and cryogenically preserved at our suppliers biobank.
Lyme disease can be cured entirely by timely initiation of appropriate antibiotics, such as amoxicillin, doxycycline, and cefuroxime. Furthermore, prompt diagnosis and early initiation of antimicrobial therapy can prevent late Lyme disease and its complications.