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Coeliac Disease

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Coeliac disease is a chronic autoimmune inflammatory disease of the small intestine affecting genetically predisposed individuals. It is caused by an aberrant adaptive immune response against gluten dietary product ingestion.

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Gluten is the dietary protein rich in cereals such as wheat, barley, and Rey. Consumption of gluten-containing food by susceptible individuals results in enteropathy with an impairment of the intestinal mucosal surface-destroying villi, eventually causing indigestion and nutritional malabsorption. It is one of the most frequent genetic disorders affecting humans, with the highest prevalence in European countries. The complete cure for the coeliac diseases is impossible; however, complete avoidance of a gluten diet or strict adherence to a gluten-free diet can aid the recovery of mucosal damage and the reversibility of disease progression. Besides, chronic conditions like ulcerative colitis, type-1 diabetes, thyroid disorder, epilepsy, Downs syndrome, and Turner syndrome can primarily increase the risk of developing celiac disease. 

Celiac Disease Symptoms and Signs:

Clinical presentation of coeliac disease is always multifaceted with slow intestinal damage progression and remains undiagnosed for years. On ingestion of gluten, celiac patients develop gut-related symptoms like abdominal pain, bloating and flatulence, indigestion, constipation, and vomiting. The patient also experiences general symptoms like anemia, fatigue, anorexia, peripheral neuropathy, ataxia, and peripheral oedema. If left untreated, it can result in severe anemia, infertility in women, osteoporosis, lactose intolerance, small bowel cancer, and severe malnutrition.In general celiac disease cause difficulty in normal eating habits of an individual. It requires changing the eating pattern and consuming special food for celiac disease.

Clinical Diagnosis of Coeliac Disease:

The suspected persons are subjected to serological testing to detect IgA/IgG anti-tissue transglutaminase antibodies (tTGA) by enzyme-linked immunosorbent assay (ELISA). They are considered the most sensitive and accurate test for diagnosing celiac disease. Besides, in tTGA-positive cases, IgA anti-endomysial antibodies (IgA EMA) tests are also employed as confirmatory tests to achieve diagnostic specificity.
Moreover, histopathological examination of endoscopy-mediated biopsy samples of small intestinal mucosa helps in the integrated assessment of the disease severity. Nevertheless, early diagnosis of the disease can reduce the risk and complications.The need to develop a new non-invasive diagnostic tool for the early diagnosis of the disease has led to a hike in research opportunities in the global diagnostic test market.

An Insight into Celiac Disease Biospecimens We Offer:

Central BioHub is dedicated to offer highly annotated human biosamples for research collected from individuals suspected and clinically confirmed with celiac disease. Bringing transparency to our trade, Central BioHub brings you ethically obtained human biospecimens for research from consented donors of variable age groups, gender, ethnicity, and body mass index (BMI).

Every celiac disease patient samples such as  serum samples and human plasma were precisely measured for gluten-triggered antibodies such as anti-deamidated gliadin IgA/ IgG, IgA anti-endomysial, and anti-tissue transglutaminase IgA/IgG. Celiac disease samples are available as small volume samples and preserved in perfect condition, and stored at <-18° Celsius. Central BioHub handles all human biospecimen under-declaration of Helsinki and the declaration of Taipei. Besides, we offer human biosamples isolated from celiac patients with or without comorbidities and undergoing celiac disease treatment with Humira (Adalimumab), presenting therapeutic concentration in blood.

Connecting global researchers and scientists to the worldwide biospecimen suppliers, Central BioHub , eases the process of human biospecimen procurement. Our innovative online platform enables the selection of the suitable high-quality research samples that you are searching for. Central BioHub promises you the fast, reliable, worldwide delivery of intended coeliac disease specimens by ensuring complete assistance to your procurement process. Contact us for more information on autoimmune disease samples.

Explore advanced search options to order Celiac disease biospecimens by clicking clinical diagnosis, ICD-10-CM codes, and laboratory parameters.

Coeliac disease is an autoimmune disease where the bodys immune system mistakenly attacks the tissues when eating a gluten-rich diet, such as wheat, barley, ray. It destroys the intestinal walls and thus impairs nutrition absorption.
Often, celiac disease causes mild discomfort. However, complications of celiac disease are mainly observed in underdiagnosed persons or those who continue to take gluten-rich food after diagnosis. Long-term complications of celiac disease include osteoporosis, malnutrition, iron deficiency anaemia, pernicious or vitamin B12 deficiency anaemia, folate deficiency anaemia, and small bowel cancer. Besides, coeliac disease during pregnancy can lead to low birth weight in newborns.
People having first-degree relatives diagnosed with coeliac disease and genetically predisposed individuals are at greater risk of developing the illness. Individuals with first-degree relatives diagnosed with coeliac disease are more likely to develop the illness. On the other hand, genetically predisposed individuals possessing a single or a pair of celiac genes, i.e. HLA-DQ2 and HLA-DQ8, contract with illness. Moreover, environmental factors play a major role in triggering the condition.
Coeliac disease samples are human biospecimens for research ethically obtained from suspected or clinically confirmed coeliac disease patients. It includes human serum and plasma samples critically measured for gluten-triggered antibodies such as anti-deamidated gliadin IgA/ IgG, anti-tissue transglutaminase IgA/IgG, IgA anti-endomysial to confirm the illness. Central BioHub offers readily available samples that are stored cryogenically at our partners biobank, complying with every safety standard protocol for biosample processing.
Celiac disease can be effectively managed by switching to a gluten-free diet. This means the patient should completely avoid gluten-containing food like wheat, barley, rye, and sometimes oats.