Influenza

Influenza (ICD Code-J10), commonly known as Flu, is a highly contagious acute respiratory infection caused by Influenza Virus A and B. Being a droplet infection, influenza is transmitted from human to human through exposure to the virus-containing respiratory secretions-large droplets produced during coughing and sneezing. Moreover, close contact with the influenza patient and contact with contaminated surfaces remains the other potential sources of disease acquisition. Often influenza occurs as a seasonal outbreak and is endemic, especially during winter hitting millions globally. Explore advanced search options by clicking CLINICAL DIAGNOSIS, ICD-10-CM CODES, and LABORATORY PARAMETERS.

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The disease incidence, the strength of epidemics, mortality, and morbidity effects of influenza depends explicitly on the community's susceptibility. Effective immunization programs by annual influenza vaccine facilitate prevention and control of the epidemic crisis. However, aiming at disease eradication, the need for continuous innovative research persists for a better understanding of the viral infection biology, genomics, immune response to the infection, and the influenza virus epidemiology.


Etiology of Influenza:

Influenza viruses, an RNA-type virus belonging to the family Orthomyxoviridae, exhibit diverse antigenic characteristics and occur in mainly three forms: A, B, and C. Influenza A Virus and Influenza B Virus re known to cause severe disease outbreaks. On the other hand, influenza virus C is generally responsible for sporadic mild upper respiratory symptoms.


Influenza-Clinical Presentation and Complications:

Infected patients usually experience an abrupt onset of flu symptoms such as  high-grade fever, myalgia, headache, malaise, and anorexia, traditionally associated with upper respiratory manifestations such as non-productive cough, sore throat, and nasal discharge. In severe viremia, multiple organs such as the lungs, brain, and heart are affected, resulting in severe complications and death. The intricacies of influenza include pulmonary complications like severe primary influenza, viral pneumonia, and secondary bacterial pneumonia. Besides, It also causes non-pulmonary complications such as myocarditis, pericarditis, Guillain–Barré syndrome, encephalitis, acute liver failure, and Reye syndrome. Therefore, timely diagnosis and early initiation of antiviral therapy can significantly reduce its catastrophic effects.

 

Clinical Diagnosis of Influenza:

Often flu symptoms is a self-limiting infection that can be confirmed by clinical presentation. However, laboratory confirmation of the disease is done by nucleic acid-based tests such as polymerase chain reaction (PCR) or rapid diagnosis kits or rarely virus isolation by culture methods.
Furthermore, rapid diagnosis influenza tests detect viral antigens in the Patient’s respiratory secretions and aids in prompt screening of the infected persons. In comparison, RT-PCR is a molecular test employed to distinguish between the types and sub-types of influenza virus that helps in achieving more specificity and sensitivity in diagnosis.


An Insight into Influenza Biospecimens We Offer:

Accelerating continuous innovative influenza research, Central BioHub offers highly annotated human influenza test samples collected from genuine donors of all ages, gender, and ethnicities suspected or clinically confirmed with influenza. Our inventory comprises highly reliable flu samples such as human serum, plasma, and respiratory secretions stored at <-18°C at our partner’s biobank . Every human biospecimen is accurately tested in certified laboratories for anti-influenza-A IgG and anti-influenza-B IgG to yield disease confirmation.


Central BioHub commits to fueling research for developing more efficient next-generation universal vaccination, specific anti-influenza therapy, and innovative diagnostic modalities to prevent future disease outbreaks. Connecting global researchers and scientists to the worldwide biospecimen suppliers, Central BioHub refines the process of human biospecimen procurement. Our innovative online platform enables the selection of the suitable high-quality research sample that you are searching for in a simplified format. In addition, Central BioHub promises you the fast, reliable, worldwide delivery of ordered biospecimens by ensuring complete assistance to your procurement process. Hurry up! Contact us today for more information on clinical research sample .

Influenza, commonly known as flu, is a highly contagious viral infection caused by the influenza A virus and influenza B virus. It can affect people regardless of age and gender, characterised by fever with chills, fatigue, cough, cold cough, body pain, headaches, vomiting, and diarrhoea.
Being a respiratory infection, influenza is transmitted from person to person through inhalation of tiny infected droplets released into the air when a sick person cough and sneeze. Besides, contact with contaminated surfaces by touching can carry the virus on the hands and cause infection.
The following ways can effectively control the occurrence and transmission of influenza: • Annual influenza (flu) vaccination or immunisation can prevent influenza • Cover your nose and mouth during sneezing and coughing • Wash your hands regularly with soap and water or use hand alcohol-based hand sanitisers. • Do not touch your face, especially your nose and mouth, with unwashed hands. • Eat nutritious diet • Stay hydrated by drinking plenty of fluids. • Take your medications as prescribed by the physician.
It includes human serum, plasma, and respiratory secretions ethically derived from persons suspected or clinically confirmed with influenza. The influenza infection samples precisely are measured for anti-Influenza-A IgG, anti-Influenza-B IgG, and cryogenically stored at our biobank.