Sepsis and septic shock samples for research | Order Online
infectious diseases sepsis

Sepsis

Sepsis is a potentially life-threatening condition resulting from the body systemic inflammatory response syndrome secondary to an infection, which eventually causes end-stage multiple organ dysfunction and death. It is also known as septicemia; if not adequately treated, it can lead to sepsis shock. Despite several medical advancements, resuscitation techniques, life support equipment, sepsis remains the significant cause of morbidity and mortality in hospitalised or critically sick patients. In addition, it remains the most prevalent nosocomial infection worldwide. Sepsis treatment mainly focus on early diagnosis and timely initiation of broad-spectrum antimicrobial therapy are warranted to prevent fatal sepsis shock and increase the sepsis survival rate. Moreover, severe sepsis infection or septic shock imposes a substantial economic or financial burden on patients and healthcare systems, often requiring intensive care unit (ICU) treatment for a long duration. Besides, growing antimicrobial resistance globally has made it often more challenging to tackle sepsis infection. Accelerate sepsis research with high-quality human specimens from Central BioHub. Explore advanced search options to procure sepsis samples by clicking CLINICAL DIAGNOSIS, ICD-10-CM CODES, and LABORATORY PARAMETERS.

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Signs and Symptoms of Sepsis:

Clinical diagnosis of sepsis disease is often challenging, which requires a greater index of suspicion to detect illness, especially in older people, due to its ambiguous nature. Most individuals experience an abrupt emergence of sepsis symptoms that rapidly evolve from one to another. General signs of sepsis and symptoms include sudden high-grade fever with chills, hyperventilation, thrombocytopenia, tachycardia, leukocytosis, neutrophilia, hypoxia, skin lesions, and altered mental sensorium due to blood poisoning and sepsis shock. Furthermore, blood biochemistry shows elevated inflammation biomarkers like C-reactive protein (CRP) and procalcitonin (PCT). Upon progression to severe sepsis infection or septic shock patient develops hypothermia, oliguria, anuria, acidosis, elevated liver enzymes, severe leukopenia, disseminated vascular coagulation, adult respiratory distress syndrome, hypotension, and shock leading to death.

Diagnosis of Sepsis:

Accurate clinical diagnosis of acute sepsis disease is crucial for effective management of infection progression. A detailed clinical investigation, including patient medical history, signs, and sepsis symptoms, increases the likelihood of accurate diagnosis. More often, sepsis infection requires multiple diagnostic modalities for disease confirmation. In addition, clinical examination for predisposing factors like trauma, surgery, organ transplantation, and previous infection enables determining the source or foci of infection.
Moreover, identification of sepsis infection aetiology through microbiological culture and antimicrobial susceptibility testing guide in tailoring specific antimicrobial therapy regimens for infection sepsis treatment.
In addition, haemogram and infection biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) aid in determining the severity of sepsis and sepsis shock. However, in hospitalised patients, pulse oximetry, complete blood count (CBC), arterial blood gases analysis, serum electrolytes, liver and kidney function tests, C-reactive protein level, and microbiological examination of blood guarantee accurate diagnostic specificity and identification of causative pathogens.

An Insight into Sepsis and septic shock  samples We Offer:

Central BioHub is a global international biospecimen provider specialised in catering human specimens for translational and precision medicine research. Simplifying the tedious biosample procurement process, Central BioHub connects certified global human biobank to biomedical researchers through a most straightforward, open access, and interoperable, user-friendly online marketplace. We supply high-quality human biospecimens that pass rigorous quality control to optimize ultimate precision in the research endpoint.

Accelerating translational, therapeutic, prognostic, and diagnostic research on sepsis, Central BioHub offers you the world’s most extensive human biospecimen inventory comprising thousands of genetically diverse sepsis biospecimens. We provide human serum and plasma samples processed from carefully collected peripheral blood from sepsis patients of different ages, gender, and ethnicities. Blood specimens are precisely examined for sepsis biomarkers like C-reactive protein (CRP), procalcitonin (PCT), bilirubin, creatinine, D-dimer, lactate dehydrogenase, and cryogenically preserved at <-18°C at our partner’s biobanks.
 
We offer sepsis research samples ranging from small to bulk volumes immediately available for purchase. Valuing our client’s time and patience, every sample request is processed promptly and shipped to your destination swiftly. Our global transport network ensures safe, reliable, speedy delivery of samples to any location. Moreover, our highly motivated and well-trained scientific experts assist you in every step of the biosample purchase process. Reach out to us today for more information on sepsis clinical Research sample  or placing an order for PCT and CRP samples such as serum and plasma samples.

Sepsis is the most serious medical emergency caused by the bodys extreme response to the infection. The pathogenic infection elsewhere in any body parts like urinary tract, lungs, skin, gastrointestinal tract quickly transfers to blood, causing blood poisoning or septicemia. More often, children, the elderly, immunocompromised people, patients with other comorbidities, and patients in ICUs are more likely to develop severe infections. Severe sepsis can lead to life-threatening septic shock.
The aetiology of sepsis can be a bacterial, viral, fungal, or parasitic infection occurring elsewhere in the body. The primary sources of infection are: • Lung infection such as pneumonia • Urinary tract infection or kidney causing urosepsis • Skin or soft tissue infection including infected open wounds, surgical site infections, and cellulitis • Abdominal infections such as pancreatitis, peritonitis, cholangitis, and cholecystitis • Bloodstream infection
The transition from acute mild sepsis to severe sepsis to septic shock is complex but can progress rapidly. Therefore, sepsis treatment requires rigorous, timely diagnosis and prompt initiation of intensive, appropriate choice of systemic antimicrobials to abate infection. Also, concurrent administration of vasoactive medications like positive inotropes to maintain blood pressure and immunotherapy is warranted. Moreover, in septic shock, the patient requires supportive care such as aggressive resuscitation, supplemental oxygen supply, haemodynamic support, and mechanical ventilation to sustain the patients life
Sepsis biospecimens we offer include human serum, plasma, whole blood samples ethically obtained from a patient diagnosed with sepsis. The blood samples are genuinely tested for sepsis biomarkers like C-reactive protein (CRP), procalcitonin (PCT), bilirubin, creatinine, D-dimer, Lactate dehydrogenase, and hyper-annotated with relevant clinical data. Every human biospecimen is cryogenically stored at biorepositories to preserve relevant biomarkers for a long time to gain the utmost research benefit.
No, sepsis is not contagious. It is the exaggerated bodys response to the infection, not the infection itself. However, the foci of infection that triggers sepsis might be infectious.