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Dengue fever

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Dengue fever is a mosquito borne infectious disease transmitted through the bite of infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito caused by dengue virus (DENV). Influenced by climate changes like rainfall, temperature, relative humidity, and unplanned rapid urbanisation, dengue fever is prevalent in tropical and subtropical regions. As a result of global warming, in recent years, a higher incidence of dengue fever has been observed in many European countries. Explore advanced search options to procure biospecimens of diseases caused by mosquitoes, by clicking CLINICAL DIAGNOSIS, ICD-10-CM CODES, and LABORATORY PARAMETERS.

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Etiology and Types of Dengue Fever:
DENV belongs to the Flaviviridae family and exists in four distinct but closely related serotypes-DENV-1, DENV-2, DENV-3, and DENV-4. The mosquito borne disease mainly occurs in two forms. Dengue fever or break-bone fever is usually an uncomplicated and self-limited febrile illness affecting muscles and joints with severe back pain and myalgia.Dengue hemorrhagic fever (DHF), on the other hand, is an intense and potentially fatal form of acute febrile illness commonly seen in children under 15 years and is characterised by cutaneous and intestinal haemorrhages induced by thrombocytopenia, haemoconcentration, hypovolaemic shock, and neurologic disturbances.

Dengue virus (DENV) mainly infects blood monocytes, lymphocytes, and endothelial cells, resulting in complement activation and consumptive coagulopathy, including thrombocytopenia. If left untreated, it can develop into dengue shock syndrome, eventually causing death.Despite the lack of definite treatment and preventive vaccination, early diagnosis and medical care access can vastly reduce the severe dengue fatality rate. In recent times, the global incidence of dengue has increased dramatically. Dengue viruses transported by the infected travellers increased the risk of developing the disease in the world population. However, effective vector control strategies to prevent the breeding of Dengue mosquitos can help in eardicating the disease.

Dengue Fever Symptoms and Signs:

Dengue is a flu-like viral infection affecting humans regardless of age. The patient experiences densue symptoms such as high-grade fever accompanied by frontal headache, retro-orbital pain, myalgia, arthralgia, nausea and vomiting, haemorrhagic manifestations, swollen glands, leukopenia, and skin rashes. Furthermore, the primary medical complications of classic dengue fever are febrile seizures and severe dehydration.

Clinical Diagnosis of Dengue fever:

The presumptive diagnosis of dengue comprises physical examination, travel history to the dengue dengue-endemic regions, and clinical evidence of thrombocytopenia. Definitive diagnosis includes serological testing for dengue virus antibodies like dengue IgG (DENG) and dengue IgM (DENM). Additionally, a single-specimen rapid molecular diagnostic tool such as RT-PCR dengue test kits and enzyme-linked immunosorbent assay test detects dengue virus serotypes and dengue nonstructural protein 1 (NS1) antigen, respectively.

Insight to the Dengue Biospecimens We Offer:

Central BioHub offers a dedicated collection of human bio specimens of individuals suspected or confirmed with dengue fever. Our biobank contains dengue clinical samples, ethically isolated from consented donors of every age, gender, and ethnicity by complying with the declaration of Helsinki and Taipei too accelearate the research on dengue treatment.

Dengue patient samples include human biofluids like human saliva, urine, whole blood, serum, and plasma samples explicitly tested for various laboratory tests like DENV SubT, dengue NS-1 (DENG NS-1), and antibody testing for Dengue IgG and IgM stored at our biobank in perfect condition at <-18 or <-80 °Celsius. Accelerating indigenous dengue research, we provide small volume samples of dengue virus laboratory samples with detailed clinical data and country or regions of sample origin.
Central BioHub connects certified global biomaterial suppliers and Life science researchers or scientists through our virtual platform. Prioritising quality and customer satisfaction, scientists worldwide can purchase indented superior quality human bio specimens online with complete assistance from our scientific experts at the Central BioHub.Hurry up, Procure Dengue fever samples online.

Dengue fever is an infectious disease caused by the dengue virus transmitted by the bite of infected Aedes mosquitoes. There are four closely related dengue viruses, namely DENV1, DENV2, DENV3, and DENV4, which cause dengue in humans. Besides fever, dengue is manifested by severe pain and stiffness in joints. Therefore, dengue fever is also known as break-bone fever.
Patients with dengue fever are advised to take plenty of rest. Presently, there is no specific treatment available for dengue fever. However, symptomatic treatment is initiated based on the signs and symptoms of the patients that include: Dehydration- drink plenty of fluid to avoid dehydration. Body pain and fever- take Acetaminophen or Paracetamol to relieve body aches and fever. Avoid mosquito bites by using insect repellents, especially in the first week of dengue virus infection, to prevent active disease transmission to others through mosquitoes bite.
Dengue fever can affect humans regardless of age, gender, race, and ethnicity. Though rare, it can result in complications like dengue hemorrhagic fever and dengue shock syndrome. Dengue haemorrhagic fever is a potentially life-threatening acute febrile fever characterised by cutaneous and intestinal bleeding caused by severe thrombocytopenia, hypovolemic shock, hemoconcentration, and neurologic disturbances, eventually leading to dengue shock syndrome and death.
Despite the lack of specific vaccination for preventing dengue fever, the following measures can prevent the occurrence of dengue, which includes: Avoid travelling to dengue-endemic areas. Use mosquito repellents to prevent mosquito bites. Wear long-sleeved shirts and pants to avoid mosquito bites. Use air conditioning and avoid opening doors and windows to abstain from mosquitoes entry into the house. Sleep under mosquito nets Eat nutritious diet Stay hydrated by drinking plenty of water. Avoid stagnant water where mosquitoes can breed
Dengue biospecimens or dengue clinical research samples are the human biofluids isolated from suspected or clinically confirmed dengue patients. It includes human serum, plasma, saliva, whole blood, and urine samples subjected to various laboratory tests like DENV SubT and dengue NS-1 (DENG NS-1) and antibody testing for Dengue IgG and IgM, and stored cryogenically at our biobank for in-vitro research.