How does Psoriasis evolve in the body?

The pathogenesis of psoriasis involves a complex interaction of multiple cell types, including keratinocytes, dendritic cells, T cells, and neutrophils, which result in an abnormal cell proliferation pattern. Disturbances in the innate and adaptive immune responses play a key role in the development of psoriatic inflammation.

Which pathways and molecules are targeted in Psoriasis treatment?

While targeted therapies have shown high clinical efficacy in inhibiting IL-23 and IL-17, psoriasis is still a treatable but non curable disease. Other drugs targeting TNF-a and interleukin receptors aim to stop the inflammation. Central BioHub supports scientists investigating these pathways with well-characterized high quality psoriasis samples that can be utilized for research.

Which forms of Psoriasis can occur?

The primary form of psoriasis is psoriasis vulgaris, but the inflammation can also affect the joints and lead to psoriatic arthritis. Guttate Psoriasis is characterized by small, drop-shaped lesions that often develop after a bacterial or viral infection and affects mostly children. Other forms of psoriasis include inverse psoriasis, pustular psoriasis, nail psoriasis or erythrodermic psoriasis.

What is the best way to treat Psoriasis?

Despite the efficacy of targeted therapies, broader-acting drugs are still commonly used due to economic factors, dosage regimes, and adverse effects. Central BioHub aims to expand the field of psoriasis treatment by supplying researchers worldwide with human serum and plasma samples originating from psoriasis patients.