Syphilis (ICD Code A51) is one of the classic venereal diseases affecting humans caused by Treponema pallidum, a spirochete. Syphilis disease remains a common sexually transmitted infection (STDs) worldwide. The pathogenic organism transmits from one person to another through unprotected sexual contact with infected mucous membranes or cutaneous lesions. On rare occasions, it can be acquired by nonsexual personal contact, accidental inoculation, or blood transfusions. Besides, syphilis disease may indeed be transmitted to a fetus from infected mothers. If not treated appropriately, syphilis may have serious health sequelae. Central BioHub offers a wide range of high quality, well-annotated samples for research stored at different human biorepositories worldwide. Check out our inventory now. Also, explore advanced search options by clicking CLINICAL DIAGNOSIS, ICD-10-CM CODES, and LABORATORY PARAMETERS.

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Syphilis – Signs and Symptoms:

Clinical presentation of syphilis infection varies from person to person with progression through multiple syphilis stages, possibly in untreated or inadequately treated patients. Primary syphilis symptoms is characterised by the appearance of painless indurated lesions (syphilis rash or syphilis chancre) on the cutaneous or mucocutaneous tissue, especially on external genitalia. Secondary syphilis infection demonstrates multisystem involvement secondary to hematogenous and lymphatic spread manifested by pruritic or nonpruritic syphilis rash, mucocutaneous lesions, flu-like symptoms lymphadenopathy. In tertiary syphilis symptom includes widespread multiorgan infections result in cardiovascular syphilis, neurosyphilis, gummatous lesions involving organs or tissues.


Clinical Diagnosis of Syphilis:

Among various diagnostic modalities, definitive diagnosis of syphilis is made through visualizing the Treponema pallidum bacterium via darkfield microscopy, though rarely performed today. Nowadays, two tier-sequential testing algorithms, including nontreponemal tests followed by treponemal tests, confirm the treponema infection. Nontreponemal serological tests such as VDRL and RPR detect biomarkers released during cellular damage from syphilis spirochete infection. In contrast, treponemal tests such as FTA-ABS, TP-PA, various EIAs, chemiluminescence immunoassays, immunoblots, and rapid treponemal assays detect treponema pallidum antibodies IgM, and to a lesser degree treponema pallidum antibodies IgA that are specific for syphilis.

An Insight into Syphilis Samples We Offer:

Discover your ideal research specimens at Central BioHub. Diving through our extensive inventory of research biospecimens will be fascinating for every biomedical researcher. Inculcating a fruitful supply relationship between certified biospecimen suppliers and buyers, Central BioHub acts as a connecting point of the virtual marketplace. Nested in Germany, Central BioHub brings you world-class human biospecimens ideal for life science research such as diagnostic research, clinical research, therapeutic research, or drug discovery. Our mission is to foster life science research to enhance the current medical care process to deliver the best patient care.

We provide you with an array of premium quality syphilis testing samples obtained from voluntary donations of suspected or clinically diagnosed syphilis patients. Conforming with every standard of the Centers for Disease Control and Prevention (CDC), our partner biorepositories stores syphilis testing blood samples such as human serum, sodium citrate plasma (apheresis) at <-18 °C with strict maintenance of its viability. The syphilis testing blood samples are genuinely measured for various syphilis diagnostic parameters like anti-syphilis IgG, anti-syphilis IgM. Besides, treponemal antigenic tests like chemiluminescence immunoassay for syphilis, Treponema pallidum particle agglutination, Treponema pallidum haemagglutination assay are also conducted. Our biospecimen inventory contains syphilis biosamples derived from ages, sex, and ethnicity, pregnant and non-pregnant patients, with explicit annotation of relevant clinical data. Reach out to us for high quality, unbiased, resilient, cost-effective human biospecimens with complete support from scientific experts at every step of biospecimen procurement.

Syphilis is a sexually transmitted disease (STD) caused by Treponema pallidum, a highly contagious bacteria. It mainly transmits through sexual intercourse through the vagina, anus, or oral. It is also transmitted from the infected mother to the newborn. If not treated adequately, syphilis causes multiple organ damage and can be life-threatening.
Syphilis is caused by a bacteria known as Treponema pallidum, which mainly transmits through sexual activity with infected people. Treponema pallidum is a highly contagious small, mobile, spiral-shaped bacterium belonging to group spirochete.
Being a sexually transmitted disease, people who engage in unprotected sexual contact with infected persons are at greater risk of syphilis. Since many patients remain asymptomatic during the early phase of illness, effective screening should be done in the following people at risk of syphilis: • Sex workers • Prisoners • People with a history of HIV or other sexually transmitted diseases • Drug abusers or illicit drug use • People who engage in unprotected sexual contact with multiple partners • Homosexual men • People living in highly prevalent areas
These are syphilis test blood samples intended for in-vitro research purposes. The serum and plasma samples derived from syphilis patients are critically measured for Treponemal antigenic tests and antibody testing like anti-syphilis IgG and anti-syphilis IgM. Complying with every safety standard, all samples are well preserved at <-180C at our partners biorepository and readily available for procurement.
Yes, early diagnosis and appropriate antibiotic therapy can offer a permanent cure for syphilis and prevent further damage. A Single-dose intramuscular benzathine penicillin G and parenteral penicillin G, procaine penicillin G, aqueous crystalline penicillin G can cure any stage of syphilis, including primary, secondary, early, or late syphilis.