How are Metabolic Disorders defined?

Metabolic disorders are the cluster of diseases that cause deviation or disruption in the normal metabolism of the human body. It is a complex disorder that increases the risk of chronic conditions like cardiovascular disorders, diabetes, and other endocrine disorders, affecting individuals regardless of age and gender.

What are the most common Metabolic Disorders?

Common metabolic disorders are Diabetes Mellitus type-1 and type-2, hemochromatosis, maple syrup urine disease, phenylketonuria, Gauchers disease, and glucose-galactose malabsorption.

Which sample matrices are available from Metabolic Disorder patients?

The following matrices are available from patient suffering from different metabolic disorders. Our inventory stores tested urine, plasma, whole blood, serum, swabs, saliva, and faeces available with complete clinical profile and laboratory reports.

How can we order Metabolic Disorders samples from Central BioHub?

Ordering samples of metabolic disorder from Central BioHub is easy. Browse our online inventory of metabolic disorders, select your interested samples by applying suitable filters and add them to your cart. Further, log in to your customer account and proceed to payment and checkout. The ordered metabolic disorder samples will be delivered to your facility in 4 to 7 business days.

FFPE and frozen tissue samples for spatial analysis

FFPE and frozen tissue samples for spatial analysis

Human tissue samples are widely being used in medical, scientific, and clinical research and are valuable resources for multiple applications. FFPE and frozen tissue samples allow scientists to conduct research on rare diseases, evaluate the efficacy of drugs or targeted therapies and discover new biomarkers. Recently, two new cutting-edge techniques became popular amongst the researchers, namely spatial transcriptomics and spatial multiplex phenotyping.

Insights into cutting-edge techniques for human tissue specimens

Spatial transcriptomics allows researchers to study gene expression in combination with information about the tissue architecture or spatial organization, resulting in the creation of a detailed gene expression map for tissues. The fundamental idea is to retain spatial information while profiling gene expression in the tissue. Thin sections of tissue are mounted onto slides that contain an arrangement of spots or arrays, each with unique molecular barcodes or capture probes. The tissue sections on the slides are then treated to allow mRNA molecules to bind to the capture probes or barcodes on the array. Since each capture probe is designed to target a specific gene or set of genes, this approach enables the identification of mRNA transcripts corresponding to the genes expressed in different locations of the tissue by applying reverse transcription and preparing sequencing libraries. Consequently, the spatial information from each array can be combined with DNA sequencing, resulting in a spatial gene expression map of the tissue.

Fuel your spatial discoveries with FFPE and frozen tissue samples

The other technique, called multiplex phenotyping, has recently gained attention due to a new combination approach, in which FFPE blocks can be used to perform spatial immunofluorescence phenotyping with multiple dyes. While traditional phenotyping methods, like flow cytometry, use single-directed labeled antibodies which can target only specific proteins one at a time, multiplex immunofluorescence phenotyping allows the simultaneous detection of several biomarkers within a single experiment due to the utilization of multiple fluorescently labeled antibodies with distinct fluorochromes. This allows researchers to visualize multiple targets simultaneously with just one panel of labelled antibodies. Upon fluorescence imaging, the obtained data can be further analysed using software for quantification to create a spatial map of biomarkers within the tissue.

Specifications in detail:

Matrix: FFPE Tissue, frozen tissue
Disease presentation: Primary/secondary tumor, NAT
Receptor status: Estrogen, progesterone, HER2
TNM staging

With over 13,000 human tissue samples in our catalogue, Central BioHub is the leading platform for researchers from all over the world to find FFPE and frozen human tissue samples that meet their needs within seconds. Find your samples, reserve and order online - fast, easy and compliant.

FFPE human tissue samples:

https://centralbiohub.de/biospecimens/tissue-bank/human-tissue-samples

Frozen tissue samples:

https://centralbiohub.de/biospecimens/tissue-bank/frozen-tissue

Complete tissue inventory:

https://centralbiohub.de/biospecimens/tissue-bank

Try our expert search with advanced filter options and explore our full online inventory. Laboratory test parameters, clinical diagnosis, histological data and many more options can be applied to ensure a convenient browsing experience of over 13,000 human tissue samples and will take your research studies to a new level. Find human tissue samples for your next discovery by clicking on clinical diagnosis, icd-10-cm codes, and laboratory parameters.